After vaccination campaigns throughout the 19th and 20th centuries, the WHO certified the eradication of smallpox in 1979. Smallpox is one of the two infectious diseases to have been eradicated, the other being rinderpest, which was unofficially declared eradicated in 2010.
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(Information from Wikipedia) Visit Googles Wonder Wheel to learn more about Smallpox.
Results from Mashpedia search on Smallpox
Sweetsearch results from Smallpox search.